NICOTINE: Risks and Benefits


Warmest greetings and appreciation for your return to my blog, one dedicated to our mission statement. . “but first, do no harm!” I have had second thoughts as to the chronology of topics I intend to discuss, as I did not begin with the true “basics,” i.e. equipment, e-liquids, battery safety, proper cleansing of your mod, vaping etiquette, types of equipment, sensible use and progression of equipment, an accurate and comprehensive glossary of common terms, etc.  But the most pressing issues, those causing the greatest degree of anxiety seem to encompass nicotine, which, by now, all vapers should know. It is a very dangerous drug when used in the wrong hands for the wrong uses and the “gateway status” to other illegal compounds (NOT BEEN DOCUMENTED) which will, as well as all of the other topics aforementioned, be covered in subsequent blog entries. Remember, your feedback is very important to me. Do not be deterred from inquiring about any issues for which you are concerned.
In keeping with continuity, I have chosen to continue informing you of the effects of nicotine (N), the deleterious effects having been almost completely covered in the last blog, but NOT completely. I entered into this business with an altruistic lean, and have every intention of making available the information I would personally like to have myself, in addition to the information our patrons wish to assimilate; that information which overlaps, or expands my knowledge of vaping, so that our patrons are informed consumers. Each and every employee in our store is required to have the basic knowledge to answer the most requested questions asked, but also knows, that it is I to whom the ultimate responsibility of informed consent belongs. I will use the same enumeration format as it obviates the necessity blogging in a uniform, fluent fashion of which would be seen in the form of prose. At the expense of being myopic, I will attempt to make my information relevant, but not in contradiction of other medical facts and concerns. So, as Jim Carrey, the Pet Detective, would say, “Well, alrighty then!”

Nicotine and Health Effects
I’m back with more vital information regarding the controversial effects of nicotine in smoking vs the unequivocal advantages of the nicotine content in e-liquids for vaping. For ease of assimilation to the reader, I will again construct my entries in enumerated facts, specifically by numbering, using AF for REFERENCED DATA and OS as an OPINION STATEMENT after appropriate entries:
1. A frequently asked question is “How does nicotine affect the fetus in pregnancy?” A study done in 2013 noted that “nicotine is only 1 of more than 40,000 compounds to which the fetus is exposed through maternal smoking. Of these, at least 30 of these compounds have been associated with adverse health outcomes to the fetus.” It is proposed that hypoxia (decreased oxygen), decreased nourishment and direct vasoconstriction (clamping down on the size of nutrient blood vessels) of placental and umbilical vessels all have a deleterious effect s on the fetus. These include adverse brain development. Nicotine causes vasoconstriction.  Effects can be seen through alterations in metabolism and neurotransmitter systems, again, resulting in abnormal fetal brain development. These effects are seen as impaired orientation, and abnormalities in muscle tone. There is also “weak” evidence suggesting the development of facial cleft deformities, e.g. cleft palates and others. There is no good evidence showing fetal nicotine withdrawal symptoms, but this could prove to be valid in future studies. ERGO, VAPING IS PROHIBITED IN PREGNANT WOMEN!  However, if you must vape during your pregnancy, make certain you are vaping e-liquid with 0 (zero) Nicotine content!  Though the studies have been in smoke from combustible tobacco products, (i.e. cigarettes), there is enough evidence to carry over the possibilities of the same effects in vaping due to the Nicotine content. Of course, studies need to be performed with pure vaping, but one should not expect grants for these studies as there is still a negative governmental bias toward grants for studies proving the deleterious effects of vaping rather than the positive effects. (AF)
2. A study done on rats showed that nicotine exposure decreased the beneficial effects of maternal estrogen causing the possibility of decreased memory formation and retention. Once again, VAPING IS PROHIBITED IN PREGNANT WOMEN (AF)
3. Studies have shown the intense addictive qualities of nicotine, as significant as cocaine and heroine WHEN USED IN THE FORM OF TOBACCO. This does not necessarily correlate exactly with nicotine in vaping, but ,again, studies need to be done purely with vaping. (AF)
4. Studies show the tobacco smoke increases the reward pathway sensitivity, the opposite of other addictive drugs such as heroin and cocaine and actually DECREASES the brain reward sensitivity.  Make no mistake, however, Nicotine is an addictive substance as found in cigarette studies, not in vaping experiments.  Anecdotally, we have found that cessation of vaping seems much easier than with cigarettes having experience with over 500 clients. (AF,OS)
Now, THE GOOD NEWS!!! SMOKING HAS BEEN SHOWN TO HAVE POSITIVE THERAPEUTIC EFFECTS, often referred to as the “Smoker’s Paradoxes.”  Studies show that administration of pure nicotine, unlike that in smoking, has positive health benefits when not exposed to tar and other substances found in cigarettes.  Studies show that smokers, presumably because of the effect of Nicotine, require less frequent repeated coronary revascularizations (coronary angioplasty and stents).
5. The risk of ulcerative colitis has been shown to be less frequent in smokers and is dose dependent (the number of cigarettes smoked) suggesting similar positive effects from vaping. (AF)
6. Smoking has been shown to decrease the risk of Kaposi’s Sarcoma, a cancerous lesion seen frequently in HIV positive individuals. This may even be shown to be more effective in vaping, supposing that the beneficial effect is due to nicotine. (AF)
7. Studies show that nicotine reduces the risks of preeclampsia in pregnancy. (AF)
8. Nicotine seems to decrease the risks of disorders such as allergic asthma. (AF)
9. Although smoking has been shown to increase the risk of Alzheimer’s disease, pure nicotine has been shown to be effective in the prevention and treatment of Alzheimer’s disease. (AF)
10. Nicotine has been shown to delay the onset of Parkinson’s disease. (AF)
11. Studies show that nicotine is effective in treatment of adults with nocturnal frontal lobe epilepsy (nightly seizures.) (AF)
12. Nicotine in lower doses has been shown to be effective in the treatment of schizophrenia. (AF)
13. Studies at Duke University have shown that nicotine is beneficial in the treatment and prevention of depression. (AF)
14. The same Duke studies have shown Nicotine to improve ADHD (adult attention deficit disorder). (AF)
15. Low dose nicotine patches have been shown to be effective in the treatment of major depressive disorders in non-smokers. (AF)
16. Nicotine (used as chewing gum or transdermal patches) has been shown to be successful, even in refractory cases, in the treatment of OCD (Obsessive Compulsive Disorders.) (AF)
17. Nicotine has the paradoxical effect of being effective in the treatment of ulcerative colitis, a severely debilitating disease. (AF)
18. The drug Nicotine is UNIQUE in that it has both a stimulant and a sedative or relaxant effect.  Users report feelings of relaxation, sharpness, calmness and alertness. (AF)
19. Research has shown that when smokers wish to achieve alertness or a stimulating effect, they take short, quick puffs, producing a low level of nicotine. Conversely, when smokers wish to achieve a sedative or calming effect, they take deep, long puffs. (AF,OS)
20. Nicotine at higher doses causes opiate effect producing calmness and a pain-killing effect. This uniqueness of Nicotine was a phenomenon described by Paul Nesbitt in his doctoral dissertation and has subsequently been referred to as “Nesbitt’s Paradox.” (AF)
21. The average cigarette, inhaled, has about 1-3 milligrams of nicotine, which causes Nicotine to reach the brain in about 7 seconds.  It is quite possible that smokers use cigarettes to self-medicate anxiety and/or depression, among the other aforementioned disease effects. Vapers may do the same in their decision of choice in the milligrams of Nicotine in their e-liquids. (OS)
Well, this completes my mini-treatise on the reported effects of nicotine. I hope you will agree that VAPING can have a very beneficial effect on your health and disposition. As an orthopaedic surgeon of 40 years, one who has passionately preached the ill-effects of smoking (including the tar and 4000 other chemicals, 30 of which have shown to be toxic) as it is well shown to increase many types of cancer including lung, gastrointestinal tract, breast, ovarian and uterine cancers, among others.  It could be that the chemicals in cigarettes reduced the effectiveness of our immune systems which are felt to ward off cancerous viruses/cells, thus lowering our resistance to cancerous diseases. (OS)
Again, please give me your feedback regarding my blog and I welcome any questions you might have regarding vaping and the products associated with vaping and will try to answer them in a timely fashion.  Doc’s Vape Escape is VERY concerned regarding your health.  I think it is important to share with you that after 35 years of NOT smoking, I now vape and have been for over a year now.  I can also tell you that I have increased my consumption of nicotine from .3 to .6 mgs as a result of this study.
The Doc / Anthony P. Dalton, MD,MMM,CMI (10×10 Certified and double boarded in Orthopaedics and Sports Medicine) #docsvapeescape #docs #nicotine #vaping #vapecartoon1

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